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SAN FRANCISCO -- Even with standouts Bryce Harper and Gio Gonzalez on the disabled list, the Washington Nationals are shutting down the team with the best record in baseball and taking over the title as the leagues hottest club. Jayson Werth hit his first homer in almost a month and drove in three runs, and the Nationals capitalized on Matt Cains erratic start to beat the San Francisco Giants 6-2 Wednesday night for their fourth straight win. "We kind of got Cain on the ropes early, got his pitch count up, got some big hits early to kind of set the tone for the game," Werth said. "Its hard to recover from." Cain (1-4) walked the first three batters he faced before Adam LaRoches two-run single during a three-run first inning. Werths solo shot in the fifth and two-run single in the ninth provided the rest of the pop for the Nationals, who have won 10 of 12, including the last three at San Francisco. Former third baseman Ryan Zimmerman made a pair of diving catches in left field to highlight a stellar defensive effort, and Tanner Roark (5-4) allowed two runs and seven hits in six-plus innings to propel Washington to another win. "Were playing great as a team right row," said Roark, who struck out four and walked none. "Just keep it going. Its exciting." Brandon Crawford and Pablo Sandoval each drove in a run for the Giants, who have lost a season-high tying three straight after winning five in a row. Cains struggles might have been the most disappointing thing of all for the Giants. In his second start since a stint on the disabled list with a strained right hamstring, the former ace reverted back to his early season woes against Washington. Cain gave up four runs and three hits in five innings, walking five and striking out four. "It was too much of a deficit to come back from. We needed a better start than that. I wanted some clean innings. I made it too difficult," Cain said. The finale of the four-game series is Thursday, but the NL East-leading Nationals already have handed San Francisco its first series loss since losing two of three at Pittsburgh from May 5-7. Before the Nationals showed up in San Francisco this week, the Giants had not lost two in a row since May 16-17 to the Marlins. The Nationals are doing it by getting contributions at the plate, on the mound and in the field. After Crawfords RBI triple in the fourth, second baseman Danny Espinosa made a diving stop on Gregor Blancos sharp grounder and threw out the speedy runner at first. Zimmerman, filling in for Harper in left, also swiped another run from San Francisco in the sixth when he made a diving catch of Crawfords slicing fly after Michael Morse doubled. "Im kind of learning on the fly," Zimmerman said. "Got a good break on it. It kept tailing away. I dove and caught it. The landing wasnt very smooth, but in the end, I caught the ball." Sandoval, scratched from the starting lineup because of an illness, singled home a run as a pinch-hitter in the seventh to whittle Washingtons lead to 4-2. Zimmerman slid in to snag Angel Pagans short fly for the third out. With his back right leg almost touching the dirt, Werth went low to launch his sixth homer of the season to put the Nationals up 4-1 in the fifth. Werth, who had not homered since May 14 at Arizona, singled with two outs in the ninth off Yusmeiro Petit to extend Washingtons lead to 6-2. Drew Storen, Tyler Clippard and Jerry Blevins each tossed a scoreless inning to help Washington finish off San Francisco again. Closer Rafael Soriano had been warming up in the bullpen before Werths single. "The best part about that is we could put the big scary guy back in his cage," Werth said, "and save him for (Thursday)." NOTES: The Nationals placed catcher Wilson Ramos on the 15-day disabled list with a strained right hamstring and called up catcher Sandy Leon from Triple-A Syracuse. ... The Giants traded left-hander David Huff back to the Yankees for cash. He was sent to San Francisco in January for cash after the Yankees signed Masahiro Tanaka. ... Tim Hudson (6-2, 1.97 ERA) takes the mound for the Giants opposite Washingtons Blake Treinen (0-2, 1.78 ERA) in Thursdays series finale. Kendall Sheffield Jersey . Less than 24 hours later, in the same arena, he tried to recreate the magic of his all-time favourite player. Hilliard scored a career-high 26 points and No. Kaleb McGary Jersey . They were expecting him there all along. The Pacers announced Friday night that George has been cleared "to return to normal basketball activity," a decision made three days after he was concussed in Game 2 of the Indiana-Miami series. http://www.cheapfalconsjerseysauthentic.com/?tag=authentic-brett-favre-jersey . "Weve given ourselves now a tougher task," said Carlyle after the Friday practice, the Toronto head coach notably chipper and upbeat throughout. "But the bottom line is we just have to win our share of games [and] not worry about what anybody else is doing. John Cominsky Jersey .ca looks back at the stories and moments that made the year memorable. Qadree Ollison Jersey . -- Washingtons Bradley Beal seemed to make every shot he took in setting a career high with 37 points. ST. LOUIS -- Adam Wainwright snapped out of a midseason funk with a complete game in his previous start for St. Louis, and Colorado saw a pitcher who still had shutdown stuff. "When Im cruising, Im ahead in the count, throwing all my pitches for strikes, trusting my defence and pounding the bottom of the zone," Wainwright said after earning his 18th win in the Cardinals 5-1 victory on Friday night. "So, doing those things, usually things work out right." Matt Holliday hit a long three-run homer to left in the first inning for the Cardinals, who stopped a three-game losing streak. The distance of Hollidays 17th homer was estimated at 467 feet. "Its fun to hit one like that," Holliday said. "I hit that about as good as I can hit a ball." Wainwright (18-9) allowed one run and six hits in eight innings with eight strikeouts and no walks. He retired his final 16 batters while improving to 7-1 against Colorado and matching Clayton Kershaw, Johnny Cueto and Madison Bumgarner for the major league lead in wins. Wainwright noted that Colorados lineup is not as formidable without Troy Tulowitzki and Carlos Gonzalez. "Theyre missing two of the best hitters in baseball and theyre still a very good lineup," Wainwright said. "Guys all through the order can hit home runs." Holliday ended a nine-game RBI drought and homered for the first time this month, sending a drive off Jorge De La Rosa (13-11) into Big Mac Land beyond left field. It was the second-longest homer at 9-year-old Busch Stadium behind Hollidays 469-foot drive against the Chicago Cubs Ryan Dempster on July 20, 2012. The NL Central-leading Cardinals stayed 2 1/2 games ahead of second-place Pittsburgh. De La Rosa allowed four runs -- three earned -- and four hits in six innings. Colorado has scored just three runs during a four-game losing streak. They had been shut out the previous two games in New York against the Mets. "We had a lot oof good at-bats," said eighth-place hitter D.ddddddddddddJ. LeMahieu, who was 0 for 4 with nothing out of the infield. "We lined out three or four times. We definitely had better at-bats than the New York series, thats for sure." De La Rosa got off to a rough start. He walked Matt Carpenter and gave up Randal Grichuks infield hit before Holliday connected. "I didnt have my best stuff," De La Rosa said. "I tried to make them put the ball in the play and my only mistake was to Holliday. It was supposed to be away and he hit it really good." Colorado, which entered first in the NL with a .274 average and 665 runs, went 2 for 9 with runners in scoring position. Nolan Arenados RBI double off the base of the left-field wall in the third ended a 21-inning scoreless drought on what Wainwright described as perhaps the "best swing Ive ever seen on my curveball on a ball that was about 56 feet." Yadier Molinas RBI double in the eighth was his first extra-base hit since July 9. Grichuk had a hit and a walk and is batting .414 (12 for 29) since being recalled Aug. 29. St. Louis has won 20 of its last 28 against the Rockies. TRAINERS ROOM Rockies: 1B Justin Morneau was taken out before the bottom of the sixth with left intercostal soreness and is day to day. Cardinals: RHP Michael Wacha, struggling to regain form after nearly two months on the DL with a shoulder injury, will be pushed back in the rotation. Rookie LHP Marco Gonzales will start instead on Sunday. UP NEXT Rockies: Franklin Morales (6-7, 5.21 ERA) pitched six scoreless innings against the Padres his last start. Cardinals: Shelby Miller (9-9, 3.83 ERA) has thrown 14 consecutive scoreless innings his last two starts and is 1-0 with a 2.31 ERA in two career outings against Colorado. WHO NEEDS LUCK? Cardinals manager Mike Matheny shaved off his beard after St. Louis lost three of four at Cincinnati. He joked it was "by demand." 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